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Literature summary extracted from

  • Schousboe, I.
    Endothelial cells express a matrix protein which binds activated factor XII in a zinc-independent manner (2006), Thromb. Haemost., 95, 312-319.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 additional information Homo sapiens roles of enzyme as a modulator of cellular adhesion, migration and vascularization ?
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Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.38 proteolytic modification high molecular mass kininogen interferes with the binding of factor XII to sulfatides and its autoactivation Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.38 umbilical vein endothelial cell i.e. HUVEC, confluent layers Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 additional information roles of enzyme as a modulator of cellular adhesion, migration and vascularization Homo sapiens ?
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 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.38 More sulfatides enhance the binding of factor XII to a matrix protein expressed during growth of the endothelial cells. Binding is independent of Zn2+ and specific for alpha-XIIa with a dissociation constant of 12.8 nM Homo sapiens